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Son Son (Japan)
Soreike! Anpanman - Minna de Hiking Game! (Japan)
Sou Setsu Ryuu (Japan) (Beta)
 (Sample).webp "Sou Setsu Ryuu II - The Revenge (Japan) (Sample)")
Sou Setsu Ryuu II - The Revenge (Japan) (Sample)
.webp "Sou Setsu Ryuu II - The Revenge (Japan)")
Sou Setsu Ryuu II - The Revenge (Japan)
.webp "Sou Setsu Ryuu III - The Rosetta Stone (Japan)")
Sou Setsu Ryuu III - The Rosetta Stone (Japan)
Space Harrier (Japan)
Space Hunter (Japan)
Space Invaders (Japan)
.webp "Space Shadow (Japan)")
Space Shadow (Japan)
.webp "Space Shuttle Project (USA)")
Space Shuttle Project (USA)
.webp "Spartan X (Japan)")
Spartan X (Japan)
.webp "Spartan X 2 (Japan)")
Spartan X 2 (Japan)
 (Virtual Console).webp "Spelunker (Japan) (Virtual Console)")
Spelunker (Japan) (Virtual Console)
Spelunker (Japan)
Spelunker (USA, Europe) (Virtual Console)
Spelunker (USA)
Spelunker II - Yuusha e no Chousen (Japan)
Spider-Man - Return of the Sinister Six (Europe)
Spider-Man - Return of the Sinister Six (USA)
Spirit Impel (World) (Aftermarket) (Unl)
 (Beta) (Unl).webp "Spiritual Warfare (USA) (Beta) (Unl)")
Spiritual Warfare (USA) (Beta) (Unl)
 (v5.1) (Unl).webp "Spiritual Warfare (USA) (v5.1) (Unl)")
Spiritual Warfare (USA) (v5.1) (Unl)
 (v6.0) (Unl).webp "Spiritual Warfare (USA) (v6.0) (Unl)")
Spiritual Warfare (USA) (v6.0) (Unl)
 (v6.1) (Unl).webp "Spiritual Warfare (USA) (v6.1) (Unl)")
Spiritual Warfare (USA) (v6.1) (Unl)
.webp "Splatterhouse - Wanpaku Graffiti (Japan)")
Splatterhouse - Wanpaku Graffiti (Japan)
Splatterhouse - Wanpaku Graffiti (World) (Namcot Collection, Namco Museum Archives Vol 1)
.webp "Spot - The Video Game (USA)")
Spot - The Video Game (USA)
Spot (Japan)
.webp "Spy Hunter (USA)")
Spy Hunter (USA)
Spy vs Spy (Europe)
.webp "Spy vs Spy (Japan)")
Spy vs Spy (Japan)
Spy vs Spy (USA)
 (Rev A).webp "Sqoon (Japan) (Rev A)")
Sqoon (Japan) (Rev A)
Sqoon (Japan)
.webp "Sqoon (USA)")
Sqoon (USA)
Square Deal (Japan) (Sample)
Square no Tom Sawyer (Japan)
 (Proto).webp "Squashed (USA) (Proto)")
Squashed (USA) (Proto)
.webp "Stack-Up (World)")
Stack-Up (World)
.webp "Stack-Up ~ Block (World)")
Stack-Up ~ Block (World)
Stadium Events (Europe)
.webp "Stadium Events (USA)")
Stadium Events (USA)
.webp "Stanley - The Search for Dr. Livingston (USA)")
Stanley - The Search for Dr. Livingston (USA)
.webp "Star Force (Europe)")
Star Force (Europe)
.webp "Star Force (Japan)")
Star Force (Japan)
 (Beta).webp "Star Force (USA) (Beta)")
Star Force (USA) (Beta)
.webp "Star Force (USA)")
Star Force (USA)
Star Gate (Japan)
 (Namcot Collection).webp "Star Luster (Japan) (Namcot Collection)")
Star Luster (Japan) (Namcot Collection)
 (Virtual Console).webp "Star Luster (Japan) (Virtual Console)")
Star Luster (Japan) (Virtual Console)
.webp "Star Luster (Japan)")
Star Luster (Japan)
 (Sample).webp "Star Soldier (Japan) (Sample)")
Star Soldier (Japan) (Sample)
Star Soldier (Japan)
Star Soldier (USA)
Star Trek - 25th Anniversary (Germany)
Star Trek - 25th Anniversary (USA)
Star Trek - The Next Generation (USA)
 (Proto).webp "Star Trek V - The Final Frontier (USA) (Proto)")
Star Trek V - The Final Frontier (USA) (Proto)
Star Versus (World) (Aftermarket) (Unl)
.webp "Star Voyager (USA)")
Star Voyager (USA)
Star Wars - The Empire Strikes Back (Europe)
Star Wars - The Empire Strikes Back (Japan)
Star Wars - The Empire Strikes Back (USA) (Beta)
Star Wars - The Empire Strikes Back (USA)
.webp "Star Wars (Europe)")
Star Wars (Europe)
Star Wars (Japan) (Namco)
Star Wars (Japan) (Victor)
Star Wars (USA) (Beta)
Star Wars (USA)
.webp "Starship Hector (USA)")
Starship Hector (USA)
StarTropics (Europe) (Virtual Console)
StarTropics (Europe)
 (Virtual Console).webp "StarTropics (USA) (Virtual Console)")
StarTropics (USA) (Virtual Console)
.webp "StarTropics (USA)")
StarTropics (USA)
Stealth ATF (Europe)
.webp "Stealth ATF (USA)")
Stealth ATF (USA)
.webp "Sted - Iseki Wakusei no Yabou (Japan)")
Sted - Iseki Wakusei no Yabou (Japan)
 (Nintendo Switch).webp "Steins;Gate (USA) (Nintendo Switch)")
Steins;Gate (USA) (Nintendo Switch)
.webp "Stick Hunter - Exciting Ice Hockey (Japan)")
Stick Hunter - Exciting Ice Hockey (Japan)
Stinger (USA) (Virtual Console)
Stinger (USA)
 (Ja) (NTSC) (Unl).webp "Strategist (Asia) (Ja) (NTSC) (Unl)")
Strategist (Asia) (Ja) (NTSC) (Unl)
Strategist (Asia) (Ja) (PAL) (Unl)
Streemerz (World) (Fr) (v02) (Aftermarket) (Unl)
 (v01) (Aftermarket) (Unl).webp "Streemerz (World) (v01) (Aftermarket) (Unl)")
Streemerz (World) (v01) (Aftermarket) (Unl)
 (v02) (Aftermarket) (Unl).webp "Streemerz (World) (v02) (Aftermarket) (Unl)")
Streemerz (World) (v02) (Aftermarket) (Unl)
.webp "Street Cop (USA)")
Street Cop (USA)
Street Fighter 2010 - The Final Fight (USA)
Street Gangs (Europe) (Virtual Console)
Street Gangs (Europe)
Street Heroes (Asia) (Ja) (Unl)
Strider (USA)
Strider Hiryu (Japan) (Proto)
 (Unl).webp "Strike Wolf (Asia) (Unl)")
Strike Wolf (Asia) (Unl)
 (Unl).webp "Stunt Kids (USA) (Unl)")
Stunt Kids (USA) (Unl)
 (Virtual Console).webp "Sugoro Quest - Dice no Senshitachi (Japan) (Virtual Console)")
Sugoro Quest - Dice no Senshitachi (Japan) (Virtual Console)
.webp "Sugoro Quest - Dice no Senshitachi (Japan)")
Sugoro Quest - Dice no Senshitachi (Japan)
Suikoden - Tenmei no Chikai (Japan)
.webp "Sukeban Deka III (Japan)")
Sukeban Deka III (Japan)
 (En).webp "Summer Carnival '92 - Recca (Japan) (En)")
Summer Carnival '92 - Recca (Japan) (En)
 (Unl).webp "Sunday Funday - The Ride (USA) (Unl)")
Sunday Funday - The Ride (USA) (Unl)
Sunman (Europe) (Proto)
Super 190-in-1 (Asia) (En) (Unl) (Pirate)
Super Adventure Quests (Europe) (Unl)
Super Arabian (Japan)
 (Demo) (Aftermarket) (Unl).webp "Super Bat Puncher (World) (Demo) (Aftermarket) (Unl)")
Super Bat Puncher (World) (Demo) (Aftermarket) (Unl)
.webp "Super Black Onyx (Japan)")
Super Black Onyx (Japan)
Super C (USA)
Super C (World) (Contra Anniversary Collection)
 (Konami Collector's Series) (Unl).webp "Super C (World) (Konami Collector's Series) (Unl)")
Super C (World) (Konami Collector's Series) (Unl)
.webp "Super Cars (USA)")
Super Cars (USA)
 (Ja) (Unl).webp "Super Cartridge Ver 1 - 4 in 1 (Asia) (Ja) (Unl)")
Super Cartridge Ver 1 - 4 in 1 (Asia) (Ja) (Unl)
 (Ja) (Unl).webp "Super Cartridge Ver 2 - 10 in 1 (Asia) (Ja) (Unl)")
Super Cartridge Ver 2 - 10 in 1 (Asia) (Ja) (Unl)
 (Ja) (Unl).webp "Super Cartridge Ver 3 - 8 in 1 (Asia) (Ja) (Unl)")
Super Cartridge Ver 3 - 8 in 1 (Asia) (Ja) (Unl)
 (Ja) (Unl).webp "Super Cartridge Ver 4 - 6 in 1 (Asia) (Ja) (Unl)")
Super Cartridge Ver 4 - 6 in 1 (Asia) (Ja) (Unl)
 (Ja) (Unl).webp "Super Cartridge Ver 5 - 7 in 1 (Asia) (Ja) (Unl)")
Super Cartridge Ver 5 - 7 in 1 (Asia) (Ja) (Unl)
Super Cartridge Ver 6 - 6 in 1 (Asia) (Ja) (Unl)
 (Ja) (Unl).webp "Super Cartridge Ver 7 - 4 in 1 (Asia) (Ja) (Unl)")
Super Cartridge Ver 7 - 4 in 1 (Asia) (Ja) (Unl)
Super Cartridge Ver 8 - 4 in 1 (Asia) (Ja) (Unl)